Having already been without Brian Carney, Gareth Hock and Dennis Moran for their 22-20 win over St Helens on Good Friday, the Warriors have now lost centre Kevin Brown (ankle), prop Danny Sculthorpe (rib), loose forward Sean O'Loughlin (knee) and stand-off Danny Orr (shoulder).
"It was a great win for us but we have paid a price," said coach Denis Betts.
The club were initially able to name only 16 players when submitting their squad but have since added youngsters James Coyle and Bryn Hargreaves to an already youthful line-up.
"It's been a struggle to name a squad for Monday's game," added Betts.
"At this stage we are not sure what our line up will be against Hull but whoever plays will be giving their usual 100% for the club."
Wigan's injury crisis comes in the wake of captain Andy Farrell's departure to rugby union and the loss of new signing Luke Davico with a serious shoulder injury.
O'Loughlin, the brother-in-law of Farrell, is thought to be the most serious new casualty and will undergo scans to determine the extent of knee damage.
Wigan 18-Man Squad:- Kris Radlisnki, Brett Dallas, Stephen Wild, David Vaealiki, Martin Aspinwall, Wayne Godwin, Terry Newton, Jerome Guisset, Jerry Seuseu, Danny Tickle, Harrison Hansen, Dave Allen, Liam Colbon, Bob Beswick, James Coyle, Paul Prescott, Bryn Hargreaves, Chris Melling.